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KMID : 1098420210290030187
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Korean Journal of Medicinal Crop Science
2021 Volume.29 No. 3 p.187 ~ p.193
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Assessment on the Biological Activities of Ethanol Extract from Marchantia polymorpha L.
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Yim Eun-Young
Choi Hyung-Soon
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Abstract
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Background: Bryophytes are a group of three non-vascular land plant divisions, consisting of approximately 18,000 species known globally. These species are divided into mosses (Bryophyta), liverworts (Marchantiophyta) and hornworts (Anthocerotophyta). Approximately 900 species of bryophytes have been recorded in Korea. However, only a small number of researchers have discovered new taxa and conducted taxonomic review. Therefore, Bryophytes are still considered an unexplored field and are difficult to use as a resource. We describes a preliminary evaluation of the biological activity on Marchantia polymorpha L., a common liverwort species.
Methods and Results: Studies on the anti-inflammatory effect were conducted to screen for biological activity. M. polymorpha was extracted using 70% ethanol (MPE). We examined the inhibitory effects of MPE on the production of pro-inflammatory factors [e. g., interleukin-1β (IL-1β), interleukin-6 (IL-6), nitricoxide (NO), and prostaglandin E2 (PGE2)] in murine macrophage cell-line RAW 264.7 activated with LPS (lipopolysaccharide). MPE decreased the production of NO and PGE2. Aditionally, MPE inhibited the production of pro-inflammatory cytokines (e. g., IL-1β, IL-6, and TNF-α).
Conclusions: These results suggest that MPE has significant effects on pro-inflammatory factors and that M. polymorpha is a possible anti-inflammatory therapeutic plant.
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KEYWORD
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Anti-inflammatory, Biological Activity, Marchantia polymorpha L., Marchantiophyta
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